Genetic link to asymptomatic COVID-19 discovered

Gene protection for COVID-19 identified

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Researchers have identified a genetic link that may explain why some individuals remain asymptomatic when contracting COVID-19.

By The Tees Editorial Desk · 8 June 2021

Microscopic view of genetic sequencing Image: Image: North Tees and Hartlepool NHS Foundation TrustOriginal source

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A led by Newcastle University has discovered that the gene HLA-DRB1*04:01 is found three times more frequently in asymptomatic people compared to those who develop severe illness. The , published in the HLA journal, this gene provides a degree of natural resistance to the virus.

The team utilised next-generation sequencing to examine HLA genes on chromosome 6, focusing on patients from the same communities to ensure the data was comparable. Findings that the gene is more prevalent in populations of European descent due to correlations with latitude and longitude.

Dr Carlos Echevarria, a respiratory consultant involved in the research, stated that this helps clarify why some people do not become ill despite exposure. noted the potential for future genetic testing to help prioritise vaccination efforts.

The research was a collaborative effort involving North Tees and Hartlepool NHS Foundation Trust, South Tees Hospitals NHS Foundation Trust, and others. The study concludes that understanding these genetic factors is essential for long-term virus defence.

Archive : This story is based on reporting originally published by North Tees and Hartlepool NHS Foundation Trust on 2021-06-08. The original source image has been and credited.